Propylene glycol

CAS No.: 57-55-6

Chemical formula: C3H8O2

Molecular weight: 76.09

EINECS No.: 200-338-0

Melting point: -60 °C (lit.)

Boiling point: 187 °C (lit.)

Density: 1.036 g/mL at 25 °C (lit.)

Vapor density: 2.62 (vs air)

Vapor Pressure: 0.08 mm Hg ( 20 °C)

Flash point: 225 °F

Storage conditions: Store at +5°C to +30°C

Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Form: Viscous Liquid

PH value: 6-8 (100g/l, H2O, 20℃)

Odor: at 100.00 %. odorless very slight alcoholic

 

Application: Propylene glycol has good solubility, less toxicity and irritation, and is widely used as a solvent, extraction solvent and preservative for injections and non-injection pharmaceutical preparations. It is a better solvent than glycerin and can dissolve many substances such as corticosteroids , many volatile oils, most alkaloids and many local anesthetics.

Propylene glycol is similar to ethanol as a bacteriostatic agent, and its efficacy in inhibiting mold is similar to glycerin and slightly lower than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film coating materials. The equal mixture with water can delay the hydrolysis of certain drugs and increase the stability of preparation products. 15%~30% propylene glycol solution and semi-solid preparation can be used as antibacterial preservative, about 15% propylene glycol topical preparation can be used as moisturizer, 10%~30% propylene glycol aerosol solvent, 10%~25 % of propylene glycol oral solution, 10% to 60% of injection preparations, and 5% to 80% of topical preparations should be used as solvents and co-solvents.

 

Stability and Storage Conditions

It is very stable at room temperature, but it will be oxidized when left open at high temperature (above 280°C); it is chemically stable after being mixed with 95% ethanol or water; it can be sterilized by autoclaving or filtration. Propylene glycol is hygroscopic and should be stored in a cool, dry place in an airtight container away from light.

 

 

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